Chronic Intermittent Hypoxia Induces Atherosclerosis

Chronic intermittent hypoxia induces atherosclerosis.

RATIONALE Obstructive sleep apnea, a condition leading to chronic intermittent hypoxia (CIH), is associated with hyperlipidemia, atherosclerosis, and a high cardiovascular risk. A causal link between obstructive sleep apnea and atherosclerosis has not been established. OBJECTIVES The objective of the present study was to examine whether CIH may induce atherosclerosis in C57BL/6J mice. METHO...

Chronic Intermittent Hypoxia Induces 112-Hydroxysteroid Dehydrogenase in Rat

Chronic intermittent hypoxia exposure induces memory impairment in growing rats.

The study was aimed to examine the effect of chronic intermittent hypoxia (CIH) on spatial memory of growing rats and to explore the possible underlying mechanisms. Sixty two rats were trained to perform the 8-arm radial maze task and were divided into four groups: 2-week-CIH (2IH) 2-week-control (2C) 4-week-CIH (4IH) and 4-week-control (4C). There were more reference memory errors, working mem...

Chronic intermittent hypoxia induces lung growth in adult mice.

Obstructive sleep apnea (OSA) increases cardiovascular morbidity and mortality, which have been attributed to intermittent hypoxia (IH). The effects of IH on lung structure and function are unknown. We used a mouse model of chronic IH, which mimics the O(2) profile in patients with OSA. We exposed adult C57BL/6J mice to 3 mo of IH with a fraction of inspired oxygen (F(I)(O(2))) nadir of 5% 60 t...

Intermittent hypoxia reduces microglia proliferation and induces DNA damage in vitro

Objective(s):Intermittent hypoxia (IH), caused by obstructive sleep apnea (OSA), could cause hippocampus or neuron damage through multiple signaling pathways, while the underlying mechanisms are still unclear. Thus, the present study aimed to explore the effect of IH on the biological functions of microglia cells. Materials and Methods:Cell proliferation of BV2 cells after exposure to IH were o...